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1492 | The Spanish conquer Granada and extinguish Moorish kingdom |
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1493 | Pope Alexander VI publishes bull Inter cetera divina dividing the New World between Spain and Portugal |
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1494 | Treaty of Tordesillas: Spain and Portugal divide New World between them    GO ! |
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1503 | The Casa Contratacción (Colonial Office) founded in Madrid to deal with American affairs |
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1504 | Treaty of Lyons - divides Italy between France (north) and Spain (south) |
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1505 | Treaty of Salamanca - Ferdinand of Aragon understakes to rule Castile jointly with his daughter Juana and her husband Philip
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1506 | Treaty of Windsor |
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1508 | The League of Cambrai formed by Margaret of Austria, the Cardinal of Rouen, and Ferdinand of Aragon for purpose of despoiling Venice |
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1509 | Pope Julius II joins League of Cambrai and excommunicates Venetian Republic; France declares war on Venice |
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1511 | Pope Julius II forms Holy League with Venice and Aragon to drive the French out of Italy |
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1513 | Treaty of Mechlin: Maximilian I, Henry VIII, the pope, and Ferdinand of Aragon agree to invade France |
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1516 | Aarchduke Charles succeeds as King of Spain on death of Ferdinand II |
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1518 | Peace of London between England, France, Emperor Maximilian I, the pope, and Spain |
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1519 | Emperor Maximilian I dies; Charles I of Spain becomes Holy Roman Emperor as Charles V |
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1519 | Hernando Cortes enters Tenochtitlan, capital of Mexico, and is received by Montezuma, the Aztec ruler |
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1521 | Hernando Cortes assumes control of Mexico after destruction of Aztec state |
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1522 | Spanish forces conquer Guatemala |
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1525 | Germans and Spanish defeat French and Swiss at Pavia: Charles V becomes master of Italy |
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1533 | Pizarro executes the Inca of Peru |
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1556 | Charles V abdicates, assigning Spain to his son Philip II, and the Holy Roman Empire to his brother Ferdinand I, and retires into the monastery of Yuste |
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1560 | Madrid becomes capital of Spain |
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1595 | Henry IV declares war on Spain |
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1597 | Second Span. Armada leaves for England; scattered by storms |
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1597 | Philip II opens peace talks with Henry IV |
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1598 | King Philip II of Spain dies; succeeded by Philip III |
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1604 | Peace between England and Spain |
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1609 | Twelve years truce between Spain and Holland |
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1621 | Philip III of Spain dies; succeeded by his son Philip IV |
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1621 | Twelve years truce between Holland and Spain ends; war resumed |
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1624 | England declares war on Spain |
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1626 | Treaty of Monzon between France and Spain confirms independence of the Grisons |
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1627 | Richelieu signs treaty with Spain |
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1635 | Peace of Prague signed between the Emperor Ferdinand II and the Elector John George of Saxony; Thirty Years' War is now a conflict between France and Sweden against the House of Hapsburg |
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1648 | Naples restored to Span. rule |
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1659 | Peace of the Pyrenees between France and Spain |
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1665 | Philip IV of Spain dies; succeeded by his son Charles II |
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1667 | Secret treaty between Louis XIV and Charles II against Spain |
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1668 | Treaty of Lisbon: Spain recognises independence of Portugal |
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1668 | Peace of Aix-la-Chapelle ends War of Devolution between France and Spain |
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1668 | Treaty between Louis XIV and Leopold I concerning future partition of Span. realms |
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1675 | King Charles II of Spain attains majority |
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1678 | Peace of Nijmegen between France and the Dutch and France and Spain |
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1683 | Spain declares war on France |
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1683 | League of The Hague: the Emperor Leopold I and Charles II of Spain join Dutch-Swed. alliance against France |
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1690 | Spain joins Great Alliance against France |
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1700 | King Charles II of Spain dies, setting the stage for the War of the Spanish Succession |