The War of the Holy League (1508–16), sometimes known as the War of the League of Cambrai, was a major conflict in the Italian Wars. The principal participants of the war were France, the Papal States, and the Republic of Venice; they were joined, at various times, by nearly every significant power in Western Europe, including Spain, the Holy Roman Empire, the Kingdom of England, the Kingdom of Scotland, the Duchy of Milan, Florence, the Duchy of Ferrara, and the Swiss.